A new study led by researchers from the University of Cincinnati College of Medicine, the Icahn School of Medicine at Mount Sinai, Errex Inc., and Teva Pharmaceuticals USA Inc. suggests that higher temperatures significantly increase the likelihood of experiencing migraine attacks. Presented at the sixty-sixth Annual Scientific Meeting of the American Headache Society in San Diego, California, the study focused on Fremanezumab’s effectiveness in preventing headaches triggered by temperature changes.

Vincent Martin, director of UC’s Headache and Facial Pain Center and a physician at UC Health, who led the study and is president of the National Headache Foundation, emphasized, “Climate changes rank among the most common migraine triggers.”

Fremanezumab, marketed as AJOVY by Teva Pharmaceuticals USA Inc., is administered via subcutaneous injection and belongs to a new class of monoclonal antibodies developed in recent years to treat migraines. These drugs target CGRP (calcitonin gene-related peptide), a protein responsible for transmitting pain signals in the brain and nervous system.

Analyzing 71,030 daily diary entries from 660 migraine patients alongside regional meteorological data, researchers found that every 10-degree Fahrenheit increase in daily temperature correlated with a 6% rise in headache occurrence. Remarkably, this association disappeared completely during Fremanezumab treatment periods.

“This study is groundbreaking in suggesting that CGRP-targeted therapies can effectively manage weather-triggered migraines,” remarked Fred Cohen, co-author of the study and assistant professor at the Icahn School of Medicine at Mount Sinai in New York. Vincent Martin added, “If further validated, this pharmacological approach holds promise in alleviating weather-related migraines for many individuals.”

Martin, also a professor at UC’s College of Medicine, highlighted, “Our findings underscore the significant impact of temperature increases on migraine onset across the United States.”

Reflecting on the study’s implications, Al Peterlin, retired chief meteorologist at the US Department of Agriculture and study co-author, noted, “Hippocrates believed in the intimate connection between weather and health. Today, we are demonstrating the critical role of weather conditions in human well-being.”

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